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| Titre : | Synthèses et Etude de Nouveaux Analogues C-Nucléosides Models a Visées Thérapeutiques (Agents Antiviraux et Antitumoraux Potentiels) | | Type de document : | texte imprimé | | Auteurs : | BELKADI Mohamed, Auteur ; ALI OTHMAN Adel, Directeur de thèse | | Année de publication : | 2007 | | Importance : | 268 p. | | Langues : | Français (fre) | | Catégories : | CHIMIE
| | Mots-clés : | glyceraldehydes 1,2:5,6-di-o-isopropylidene-d-mannitol 5-(1,2-dihydroxyethyl)-3h-{1,3,4}oxadiazole-2-thione 1-(5-mercapto-4h-{1,2,4}triazole-3-yl)-ethane-1,2-diol c-nucleosides | | Résumé : | The 5-(1,2-dihydroxy-ethyl)-3h-{1,3,4}oxadiazole-2-thione (12) and 1-(5-mercapto-4h-{1,2,4tiazole-3-yl)-ethane-1,2-diol (13)derived from glyceraldehyde ( resembles trioses) have been synthesized from glycerol (1) via a common route the synthesis of the optical active 5-(2,2-dimethyl-{1,3}dioxolan -4-yl)-3h-{h-{1,3,4}oxadiazome-2-thione ( 17)and 5-(2,2-dimethyl-{1,3}dioxolan-4-yl)-4h-{1,2,4}triazole-3-thiol (18)may be achieved by the same common route when the D-glveraldehyde(3)was obtained by cleavage oxidation of 1,2:5,6-Di-o-isopropylidene D-mannitol (15)similar derivatives 23 end 24 of D-xylose (19)(resembles pentoses) may also be synthesized by the same common route from ( tetrahydro-{1,3}dioxino {5,4-d}{1,3}dioxin-4-yl)-methanol (21)this common route provides a simple synthetic pathway to acyclic c-nucleosides and to less extent to cyclic c-nucléosides.
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Synthèses et Etude de Nouveaux Analogues C-Nucléosides Models a Visées Thérapeutiques (Agents Antiviraux et Antitumoraux Potentiels) [texte imprimé] / BELKADI Mohamed, Auteur ; ALI OTHMAN Adel, Directeur de thèse . - 2007 . - 268 p. Langues : Français ( fre) | Catégories : | CHIMIE
| | Mots-clés : | glyceraldehydes 1,2:5,6-di-o-isopropylidene-d-mannitol 5-(1,2-dihydroxyethyl)-3h-{1,3,4}oxadiazole-2-thione 1-(5-mercapto-4h-{1,2,4}triazole-3-yl)-ethane-1,2-diol c-nucleosides | | Résumé : | The 5-(1,2-dihydroxy-ethyl)-3h-{1,3,4}oxadiazole-2-thione (12) and 1-(5-mercapto-4h-{1,2,4tiazole-3-yl)-ethane-1,2-diol (13)derived from glyceraldehyde ( resembles trioses) have been synthesized from glycerol (1) via a common route the synthesis of the optical active 5-(2,2-dimethyl-{1,3}dioxolan -4-yl)-3h-{h-{1,3,4}oxadiazome-2-thione ( 17)and 5-(2,2-dimethyl-{1,3}dioxolan-4-yl)-4h-{1,2,4}triazole-3-thiol (18)may be achieved by the same common route when the D-glveraldehyde(3)was obtained by cleavage oxidation of 1,2:5,6-Di-o-isopropylidene D-mannitol (15)similar derivatives 23 end 24 of D-xylose (19)(resembles pentoses) may also be synthesized by the same common route from ( tetrahydro-{1,3}dioxino {5,4-d}{1,3}dioxin-4-yl)-methanol (21)this common route provides a simple synthetic pathway to acyclic c-nucleosides and to less extent to cyclic c-nucléosides.
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