trié(s) par (Pertinence décroissant(e), Titre croissant(e)) 

Methods in microarray normalization (2008)

Public ISBD Titre : Methods in microarray normalization Type de document : texte imprimé Auteurs : Phillip Stafford, Éditeur scientifique Editeur : Boca Raton : CRC press Année de publication : 2008 Collection : Drug discovery series, ISSN 2380-9574 num. 10 Importance : 1 vol. (xvi-284 p.-[20] p. de pl.) Présentation : ill. Format : 25 cm ISBN/ISSN/EAN : 978-1-4200-5278-7 Langues : Anglais (eng) Index. décimale : 572.8 Résumé : Scientists can use molecular profiling microarrays to compare healthy cells with their diseased counterparts and develop gene-specific treatments. Finding the best way to interpret original profiling data into accurate trends, however, continues to drive the development of normalization algorithms and software tools. Methods in Microarray Normalization compiles the most useful and novel techniques for the first time into a single, organized source. Experts in the field provide a diverse view of the mathematical processes that are important in normalizing data and avoiding inherent systematic biases. They also review useful software, including discussions on key algorithms, comparative data, and download locations. The book discusses the use of early normalization techniques for new profiling methods and includes strategies for assessing the utility of various normalization algorithms. It presents the latest microarray innovations from companies such as Agilent, Affymetrix, and GeneGo as well as new normalization methods for protein and CGH arrays, many of which are applicable for antibody, microRNA, methylation, and siRNA arrays. Methods in Microarray Normalization provides scientists with a complete resource on the most effective tools available for maximizing microarray data in biochemical research. Note de contenu : A Comprehensive Analysis of the Effect of Microarray Data Preprocessing Methods on Differentially Expressed Transcript Selection; M. Ray, J. Freudenberg, and W. Zhang Differentiation Detection in Microarray Normalization; L.M. Li and C. Cheng Preprocessing and Normalization for Affymetrix GeneChip Expression Microarrays; B. Bolstad Spatial Detrending and Normalization Methods for Two-Channel DNA and Protein Microarray Data; A. Laurentiu Tarca, S. Draghici, R. Romero, and M. Tainsky A Survey of cDNA Microarray Normalization and a Comparison by k-NN Classification; W. Wu and E.P. Xing Technical Variation in Modeling the Joint Expression of Several Genes; W. Liggett Biological Interpretation for Microarray Normalization Selection; P. Stafford and Y. Tak Methodology of Functional Analysis for Omics Data Normalization; A. Perlina, T. Nikolskaya, and Y. Nikolsky Exon Array Analysis for the Detection of Alternative Splicing; P. Gardina and Y. Turpaz Normalization of Array CGH Data; B. Curry, J. Ghosh, and C. Troup SNP Array-Based Analysis for Detection of Chromosomal Aberrations and Copy Number Variations; B. Bolstad, S. Ghosh, and Y. Turpaz Index Spatial detrending and normalization methods for two-channel DNA and protein microarray data A survey of cDNA microarray normalization and a comparison by k-NN classification Technical variation in modeling the joint expression of several genes Biological interpretation for microarray normalization selection Methodology of functional analysis for omics data normalization Exon array analysis for the detection of alternative splicing Normalization of array CGH data SNP array-based analysis for the detection of chromosomal aberrations and copy number variations Methods in microarray normalization [texte imprimé] / Phillip Stafford, Éditeur scientifique . - Boca Raton : CRC press, 2008 . - 1 vol. (xvi-284 p.-[20] p. de pl.) : ill. ; 25 cm. - (Drug discovery series, ISSN 2380-9574; 10) . ISBN : 978-1-4200-5278-7 Langues : Anglais (eng) Index. décimale : 572.8 Résumé : Scientists can use molecular profiling microarrays to compare healthy cells with their diseased counterparts and develop gene-specific treatments. Finding the best way to interpret original profiling data into accurate trends, however, continues to drive the development of normalization algorithms and software tools. Methods in Microarray Normalization compiles the most useful and novel techniques for the first time into a single, organized source. Experts in the field provide a diverse view of the mathematical processes that are important in normalizing data and avoiding inherent systematic biases. They also review useful software, including discussions on key algorithms, comparative data, and download locations. The book discusses the use of early normalization techniques for new profiling methods and includes strategies for assessing the utility of various normalization algorithms. It presents the latest microarray innovations from companies such as Agilent, Affymetrix, and GeneGo as well as new normalization methods for protein and CGH arrays, many of which are applicable for antibody, microRNA, methylation, and siRNA arrays. Methods in Microarray Normalization provides scientists with a complete resource on the most effective tools available for maximizing microarray data in biochemical research. Note de contenu : A Comprehensive Analysis of the Effect of Microarray Data Preprocessing Methods on Differentially Expressed Transcript Selection; M. Ray, J. Freudenberg, and W. Zhang Differentiation Detection in Microarray Normalization; L.M. Li and C. Cheng Preprocessing and Normalization for Affymetrix GeneChip Expression Microarrays; B. Bolstad Spatial Detrending and Normalization Methods for Two-Channel DNA and Protein Microarray Data; A. Laurentiu Tarca, S. Draghici, R. Romero, and M. Tainsky A Survey of cDNA Microarray Normalization and a Comparison by k-NN Classification; W. Wu and E.P. Xing Technical Variation in Modeling the Joint Expression of Several Genes; W. Liggett Biological Interpretation for Microarray Normalization Selection; P. Stafford and Y. Tak Methodology of Functional Analysis for Omics Data Normalization; A. Perlina, T. Nikolskaya, and Y. Nikolsky Exon Array Analysis for the Detection of Alternative Splicing; P. Gardina and Y. Turpaz Normalization of Array CGH Data; B. Curry, J. Ghosh, and C. Troup SNP Array-Based Analysis for Detection of Chromosomal Aberrations and Copy Number Variations; B. Bolstad, S. Ghosh, and Y. Turpaz Index Spatial detrending and normalization methods for two-channel DNA and protein microarray data A survey of cDNA microarray normalization and a comparison by k-NN classification Technical variation in modeling the joint expression of several genes Biological interpretation for microarray normalization selection Methodology of functional analysis for omics data normalization Exon array analysis for the detection of alternative splicing Normalization of array CGH data SNP array-based analysis for the detection of chromosomal aberrations and copy number variations

Exemplaires (2)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
02785	20g-01-40	livres	Bibliothèque de la faculté S.N.V * HARCHE MERIEM*	livres	prêt possible Disponible
02784	20g-01-40	livres	Bibliothèque de la faculté S.N.V * HARCHE MERIEM*	livres	Consultation sur place Exclu du prêt

Principles of toxicology testing / Franck A. Barile (2013)

Public ISBD Titre : Principles of toxicology testing Type de document : texte imprimé Auteurs : Franck A. Barile, Auteur Mention d'édition : 2nd ed. Editeur : Boca Raton : CRC press Année de publication : 2013 Importance : 1 vol. (XI-354 p.) Présentation : ill. Format : 26 cm ISBN/ISSN/EAN : 978-1-84214-528-9 Note générale : Notes bibliogr. Langues : Anglais (eng) Index. décimale : 615.9 Résumé : Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation of in vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development of in vitro methodologies. This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory. Note de contenu : This book comprises 23 chapters in three sections: basic concepts; testing in vivo; and testing in vitro, laid out in clear typeface with excellent illustrations and diagrams ... Culture and test procedures or protocols are clearly laid out in a flow diagram format that seem easy to follow. Principles of toxicology testing [texte imprimé] / Franck A. Barile, Auteur  . -  2nd ed. . - Boca Raton : CRC press, 2013 . - 1 vol. (XI-354 p.) : ill. ; 26 cm. ISBN : 978-1-84214-528-9 Notes bibliogr. Langues : Anglais (eng) Index. décimale : 615.9 Résumé : Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation of in vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development of in vitro methodologies. This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory. Note de contenu : This book comprises 23 chapters in three sections: basic concepts; testing in vivo; and testing in vitro, laid out in clear typeface with excellent illustrations and diagrams ... Culture and test procedures or protocols are clearly laid out in a flow diagram format that seem easy to follow.

Exemplaires (1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
02133	20t-01-05	livres	Bibliothèque de la faculté S.N.V * HARCHE MERIEM*	livres	Consultation sur place Exclu du prêt

---

1 (1 - 2 / 2)